Race Result
| GP n. 346 - 03/05/1981 - Grand Prix of San Marino Autodromo Enzo e Dino Ferrari |
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| Winner: | Nelson Piquet / Brabham-Ford - 1:51'23.97 | ||||||
| Pole Position: | Gilles Villeneuve / Ferrari - 1:34.523 | ||||||
| Fastest Lap: | Gilles Villeneuve / Ferrari - 1:48.064 | ||||||
| Pos | Nš | Driver | Constructor | Laps | Time/Retired | Grid | Points |
| 1 | 5 |  Nelson Piquet |
Brabham-Ford | 60 | 1:51'23.97 | 5 | 9 |
| 2 | 29 |  Riccardo Patrese |
Arrows-Ford | 60 | + 4.58 | 9 | 6 |
| 3 | 2 |  Carlos Reutemann |
Williams-Ford | 60 | + 6.34 | 2 | 4 |
| 4 | 6 |  Hector Rebaque |
Brabham-Ford | 60 | + 22.89 | 13 | 3 |
| 5 | 28 |  Didier Pironi |
Ferrari | 60 | + 25.87 | 6 | 2 |
| 6 | 8 | Andrea de Cesaris |
McLaren-Ford | 60 | + 1'06.61 | 14 | 1 |
| 7 | 27 |  Gilles Villeneuve |
Ferrari | 60 | + 1'41.97 | 1 | 0 |
| 8 | 16 | Rene Arnoux |
Renault | 59 | + 1 lap | 3 | 0 |
| 9 | 14 |  Marc Surer |
Ensign-Ford | 59 | + 1 lap | 21 | 0 |
| 10 | 7 |  John Watson |
McLaren-Ford | 58 | + 2 laps | 7 | 0 |
| 11 | 33 | Patrick Tambay |
Theodore-Ford | 58 | + 2 laps | 16 | 0 |
| 12 | 1 |  Alan Jones |
Williams-Ford | 58 | + 2 laps | 8 | 0 |
| 13 | 10 |  Slim Borgudd |
ATS-Ford | 57 | +3 lap | 24 | 0 |
| Nc | 25 | Jean Pierre Jabouille |
Ligier-Matra | 45 | not classified | 18 | 0 |
| Ret | 17 |  Eliseo Salazar |
March-Ford | 38 | spun off | 23 | 0 |
| Ret | 32 | Beppe Gabbiani |
Osella-Ford | 31 | collision | 20 | 0 |
| Ret | 4 | Michele Alboreto |
Tyrrell-Ford | 31 | collision | 17 | 0 |
| Ret | 23 | Bruno Giacomelli |
Alfa Romeo | 28 | collision | 11 | 0 |
| Ret | 3 |  Eddie Cheever |
Tyrrell-Ford | 28 | collision | 19 | 0 |
| Ret | 22 | Mario Andretti |
Alfa Romeo | 26 | gear box | 12 | 0 |
| Ret | 20 |  Keke Rosberg |
Fittipaldi-Ford | 14 | engine | 15 | 0 |
| Ret | 26 | Jacques Laffite |
Ligier-Matra | 7 | suspension | 10 | 0 |
| Ret | 15 | Alain Prost |
Renault | 3 | gear box | 4 | 0 |
| Ret | 31 | Miguel Angel Guerra |
Osella-Ford | 0 | accident | 22 | 0 |
| Dnq | 30 | Siegfried Stohr |
Arrows-Ford | did not qualify | 0 | ||
| Dnq | 9 |  Jan Lammers |
ATS-Ford | did not qualify | 0 | ||
| Dnq | 21 | Chico Serra |
Fittipaldi-Ford | did not qualify | 0 | ||
| Dnq | 18 |  Derek Daly |
March-Ford | did not qualify | 0 | ||
| Dnq | 35 | Brian Henton |
Toleman-Hart | did not qualify | 0 | ||
| Dnq | 36 | Derek Warwick |
Toleman-Hart | did not qualify | 0 | ||