Race Result
| GP n. 458 - 19/06/1988 - Grand Prix of the United States Detroit |
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| Winner: | Ayrton Senna / McLaren-Honda - 1:54'56.035 | ||||||
| Pole Position: | Ayrton Senna / McLaren-Honda - 1:40.606 | ||||||
| Fastest Lap: | Alain Prost / McLaren-Honda - 1:44.836 | ||||||
| Pos | Nš | Driver | Constructor | Laps | Time/Retired | Grid | Points |
| 1 | 12 |  Ayrton Senna |
McLaren-Honda | 63 | 1:54'56.035 | 1 | 9 |
| 2 | 11 |  Alain Prost |
McLaren-Honda | 63 | +38.713 | 4 | 6 |
| 3 | 20 |  Thierry Boutsen |
Benetton-Ford | 62 | + 1 lap | 5 | 4 |
| 4 | 22 |  Andrea de Cesaris |
Rial-Ford | 62 | + 1 lap | 12 | 3 |
| 5 | 3 |  Jonathan Palmer |
Tyrrell-Ford | 62 | + 1 lap | 17 | 2 |
| 6 | 23 | Pierluigi Martini |
Minardi-Ford | 62 | + 1 lap | 16 | 1 |
| 7 | 29 | Yannick Dalmas |
Lola-Ford | 61 | + 2 laps | 24 | 0 |
| 8 | 36 | Alex Caffi |
Dallara-Ford | 61 | + 2 laps | 21 | 0 |
| 9 | 4 | Julian Bailey |
Tyrrell-Ford | 59 | spun off | 22 | 0 |
| Ret | 24 |  Luis Perez-Sala |
Minardi-Ford | 54 | gear box | 25 | 0 |
| Ret | 33 | Stefano Modena |
Euro Brun-Ford | 46 | spun off | 19 | 0 |
| Ret | 30 | Philippe Alliot |
Lola-Ford | 46 | halfshaft | 14 | 0 |
| Ret | 27 | Michele Alboreto |
Ferrari | 45 | collision | 3 | 0 |
| Ret | 25 | Rene Arnoux |
Ligier-Judd | 45 | overheating | 20 | 0 |
| Ret | 15 | Mauricio Gugelmin |
March-Judd | 34 | engine | 13 | 0 |
| Ret | 32 |  Oscar Larrauri |
Euro Brun-Ford | 26 | gear box | 23 | 0 |
| Ret | 1 | Nelson Piquet |
Lotus-Honda | 26 | spun off | 8 | 0 |
| Ret | 6 | Riccardo Patrese |
Williams-Judd | 26 | engine | 10 | 0 |
| Ret | 17 | Derek Warwick |
Arrows-Megatron | 24 | spun off | 9 | 0 |
| Ret | 5 | Nigel Mansell |
Williams-Judd | 18 | engine | 6 | 0 |
| Ret | 14 | Philippe Streiff |
AGS-Ford | 15 | suspension | 11 | 0 |
| Ret | 18 |  Eddie Cheever |
Arrows-Megatron | 14 | electrical | 15 | 0 |
| Ret | 19 | Alessandro Nannini |
Benetton-Ford | 14 | suspension | 7 | 0 |
| Ret | 21 | Nicola Larini |
Osella | 7 | engine | 26 | 0 |
| Ret | 28 |  Gerhard Berger |
Ferrari | 6 | puncture | 2 | 0 |
| Ret | 26 |  Stefan Johansson |
Ligier-Judd | 2 | overheating | 18 | 0 |
| Dnq | 31 | Gabriele Tarquini |
Coloni-Ford | did not qualify | 0 | ||
| Dnq | 2 |  Satoru Nakajima |
Lotus-Honda | did not qualify | 0 | ||
| Dnq | 9 | Piercarlo Ghinzani |
Zakspeed | did not qualify | 0 | ||
| Dnq | 10 |  Bernd Schneider |
Zakspeed | did not qualify | 0 | ||
| Dns | 16 | Ivan Capelli |
March-Judd | accident | 0 | ||